Additionally, the role of high-mobility group box 1 (HMGB1) in tumor-bearing status was examined.<h4>Results</h4>Compared with control mice, LLC- and KLN205-bearing mice showed a tendency toward increased expression of at least one of PAI-1, vWF, and ICAM-1 on endothelium, along with inflammatory cell infiltration in the lungs. This evidence concerns the gene SERPINE1 and neoplasm.