However, mechanisms of CAR T-cell resistance in DMG settings remain unknown.<h4>Methods</h4>We compared the efficacy of B7-H3 CAR T-cells between SJ-DIPGX7c (DMG) and U87-MG (adult glioblastoma) patient-derived cell lines and showed impaired efficacy both in vitro and in vivo. Here, CD276 is linked to glioblastoma.