MAPT and early-onset autosomal dominant Alzheimer disease: In this study, proteomic analysis was performed to identify O-GlcNAc-modified proteins in both L1 larval and adult stages of wild-type N2 and of aex-3p::Tau(V337M) transgenic Caenorhabditis elegans, a nematode model of ageing and Alzheimer's disease (AD) using high-resolution nano-LC-ESI mass spectrometry.