Although game-based learning may enhance patient engagement, evidence regarding its effectiveness in adult populations remains limited.<h4>Objective</h4>To evaluate the effect of a game-based education program on treatment compliance (primary outcome) and anxiety levels (secondary outcome) in adults with T2DM receiving insulin therapy.<h4>Methods</h4>This randomized controlled study included 72 adults with T2DM who were assigned to either a game-based education group (n = 36) or a standard lecture-based education group (n = 36). The gene discussed is INS; the disease is type 2 diabetes mellitus.