More recently, iatrogenic Alzheimer disease (iAD) was described in recipients of cadaveric pituitary-derived human growth hormone (c-hGH) contaminated with Aβ amyloid seeds.<h4>Objective</h4>To describe the clinical and postmortem findings in iAD.<h4>Design, setting, and participants</h4>This case series describes 4 c-hGH recipients who were referred to the UK National Prion Clinic. Here, GH1 is linked to early-onset autosomal dominant Alzheimer disease.