These data were analyzed during February and March 2025.<h4>Exposure</h4>c-hGH contaminated with Aβ amyloid seeds.<h4>Main outcomes and measures</h4>Clinical and histopathological description.<h4>Results</h4>The study describes 4 males who developed dementia following confirmed or suspected c-hGH treatment in childhood (age at symptom onset between 47 and 60 years) with cognitive syndromes characterized by prominent language involvement. Here, GH1 is linked to dementia.