IL18 and chronic kidney disease: <h4>Introduction</h4>Interleukin-18 (IL-18) is a pro-inflammatory cytokine associated with inflammaging and cellular senescence in chronic kidney disease (CKD).<h4>Objective</h4>To evaluate longitudinal changes in plasma IL-18 levels in incident hemodialysis (HD) patients.<h4>Methods</h4>An observational longitudinal study was conducted, with blood and anthropometric data collected at baseline, 6, and 12 months.