In mice, morning coffee administration reduced fasting plasma glucose and serum insulin levels, improved glucose tolerance, and lowered proinflammatory cytokines (IL-1β, IL-6, ICAM-1, MCP-1).<h4>Conclusion</h4>Drinking coffee in the morning may be more strongly associated with a lower insulin resistance than drinking coffee later in the day. The gene discussed is IL1B; the disease is Insulin resistance.