In mice, morning coffee administration reduced fasting plasma glucose and serum insulin levels, improved glucose tolerance, and lowered proinflammatory cytokines (IL-1β, IL-6, ICAM-1, MCP-1).<h4>Conclusion</h4>Drinking coffee in the morning may be more strongly associated with a lower insulin resistance than drinking coffee later in the day. This evidence concerns the gene ICAM1 and Insulin resistance.