Moreover, numerous studies have been conducted to examine proteins (including PLCγ2 and CARD9) in signal transduction following Fcγ-receptor activation in <i>in vitro</i> and <i>in vivo</i> experimental pemphigoid models, and an increasing number of case studies involving JAK inhibitors report the successful application of these drugs in various pemphigoid diseases. Here, PLCG2 is linked to autoimmune bullous skin disease.