Mendelian randomization analysis suggested that high levels of MPHOSPH6 and ENO1 are risk factors for psoriasis.<h4>Conclusion</h4>MPHOSPH6, ENO1, MKI67, and FABP5 are identified as lactylation-related biomarkers for psoriasis, with MPHOSPH6 and ENO1 overexpression posing as risk factors. The gene discussed is ENO1; the disease is psoriasis.