Using lipopolysaccharide (LPS)-induced ALI mice and RAW264.7 inflammatory injury models, the JAK2/STAT3 signaling axis was validated by western blotting and immunofluorescence.<h4>Results</h4>TG101209 alleviated pulmonary inflammation, improved lung function, inhibited M1 polarization, and promoted M2 polarization. This evidence concerns the gene STAT3 and inflammatory response.