Potential consequences of NVU disruption include immune-driven vascular inflammation and leukocyte infiltration in Multiple Sclerosis (MS), protease-mediated tight junction degradation in ischemic stroke (IS), <i>α</i>-synuclein-associated endothelial dysfunction in Parkinson's Disease (PD), amyloid-<i>β</i>- and tau-induced pericyte injury in Alzheimer's Disease (AD), and complement-mediated vascular damage in Amyotrophic Lateral Sclerosis (ALS). Here, MAPT is linked to ischemic stroke.