Western blot analysis was performed to evaluate the expression of mitochondria-related genes (BCAT2, CASP8, EPHX2, and UCP2) and components of the AMPK-SIRT1-PGC-1α signaling pathway.<h4>Results</h4>A total of eight mitochondria-related differentially expressed genes associated with ZB treatment of T2DM were identified. This evidence concerns the gene UCP2 and type 2 diabetes mellitus.