&lt;i&gt;Lycium barbarum&lt;/i&gt; polysaccharides as prebiotics prevent colorectal cancer liver metastasis in non-alcoholic fatty liver disease by modulating gut microbiota-&lt;i&gt;FGF21-PI3K-AKT&lt;/i&gt; axis. Here, FGF21 is linked to metabolic dysfunction-associated steatotic liver disease.