TRIM37 and mulibrey nanism: However, <i>in silico</i> analysis predicted that both variants are damaging, and both amino acid positions are fairly well conserved.<h4>Conclusion</h4>These findings highlight the critical role of the <i>TRIM37</i> genetic variants in complex congenital heart defect phenotypes associated with Mulibrey nanism and emphasize the importance of comprehensive triobased WES for antenatal care and early diagnosis.