However, <i>in silico</i> analysis predicted that both variants are damaging, and both amino acid positions are fairly well conserved.<h4>Conclusion</h4>These findings highlight the critical role of the <i>TRIM37</i> genetic variants in complex congenital heart defect phenotypes associated with Mulibrey nanism and emphasize the importance of comprehensive triobased WES for antenatal care and early diagnosis. Here, TRIM37 is linked to congenital heart disease.