Additionally, elevated CRP and Progranulin levels were linked to worse outcomes, and Progranulin was a novel independent risk factor for patient death.<h4>Conclusion</h4>Serum PTEN and Progranulin are promising diagnostic biomarkers for severe pneumonia in elderly patients, with Progranulin showing prognostic value in particular. The gene discussed is CRP; the disease is susceptibility to pneumonia measurement.