To understand if IL-23 is exclusively produced by cells that may bind monomeric, therapeutic IgG, single-cell RNA sequencing (scRNAseq) and spatial transcriptomic analysis were used to evaluate the overlap of IL23A and FCGR1A (CD64) transcripts in cells isolated from the skin of patients with psoriasis (PsO) and intestine of patients with inflammatory bowel disease (IBD), respectively. This evidence concerns the gene IL23A and psoriasis.