In addition, the gene expression of IL6, CXCL1/3/5/6/8, CCL2/7, and MMP9 of synoviocytes and chondrocytes stimulated by Ti6Al4V alloy particles confirms the interconnectivity between infection- and wear particle-associated mechanisms, which discriminates some traditional soluble infection-associated biomarkers. Here, CXCL1 is linked to infection.