Weight, height, arterial blood pressure, body composition, and metabolic/endocrine parameters were compared in L-VAI versus H-VAI groups.<h4>Results</h4>Subjects in the H-VAI group (∼40%) showed greater truncal fat mass and lower adiponectin/leptin ratio (Ad/Lep), as well as greater indices of insulin resistance (HOMA-IR and triglyceride/glucose) and the metabolic syndrome severity score. The gene discussed is ADIPOQ; the disease is Insulin resistance.