<i>Results</i>: Under a dominant model, the variant genotypes (AA+CA) of the VEGF<i>-2578C/A</i> polymorphism -2578 A showed increased odds of adenomyosis versus CC (adjusted OR = 4.00, 95% CI: 1.48-10.84; <i>p</i> = 0.0037). This evidence concerns the gene VEGFA and adenomyosis.