<b>Conclusions</b>: The novel [<sup>52</sup>Mn]Mn-BPPA-bevacizumab tracer exhibits satisfactory in vitro and in vivo stability for PET imaging, high VEGF-A-specific tumor uptake, and markedly improved tumor-to-background ratios compared to the previously published DOTAGA-based probe. Here, VEGFA is linked to neoplasm.