The aim of this study was to analyze the protein-expression profile of <i>HTR4</i> and <i>PDE4D</i> genes in patients with glioma by immunohistochemical (IHC) analysis, to determine whether some interrelationship between them exists, to correlate their expression with clinical and histopathological parameters and therapy, and to determine their impact on patients' survival. The gene discussed is PDE4D; the disease is central nervous system cancer.