However, whether the cell cycle arrest effect of curcumol is related to SKP2's function in cancer cells and its mechanisms are still unclear.<h4>Objective</h4>To investigate the role of SKP2 in curcumol-induced cell cycle arrest and its underlying mechanisms.<h4>Materials and methods</h4>Transcriptomic and proteomic analyses were used to screen the ubiquitination-related factors in curcumol treated hepatocellular carcinoma cells. The gene discussed is SKP2; the disease is cancer.