We recently identified that a protein molecule, the amino-terminus region of the dense granule protein 6 (GRA6Nt) of <i>Toxoplasma gondii</i>, selectively activates innate expressions of IFN-γ and IL-18 and functions as a powerful adjuvant when used in immunization with nonreplicable (treated with mitomycin C or irradiated) MC38 CRC cells to potently activate the cytotoxic activity and IFN-γ production of CD8<sup>+</sup> T cells against cancer cells. This evidence concerns the gene IFNG and cancer.