Polyploid/CNG tumors did not show significant enrichment for canonical CRC driver mutations (<i>RAS</i>, <i>TP53</i>, <i>SMAD4</i>), although trends toward co-occurrence with <i>BRAF</i> mutation and mutual exclusivity with <i>HER2</i> amplification were observed. Here, ERBB2 is linked to colorectal carcinoma.