High-risk individuals included those with Peutz-Jeghers syndrome (132-140-fold risk), hereditary pancreatitis (50-87-fold risk), Familial Atypical Multiple Mole Melanoma syndrome (up to 48-fold risk), hereditary breast and ovarian cancer with BRCA2 mutation (up to 22-fold risk), and familial pancreatic cancer with at least three affected relatives (up to 32-fold risk). This evidence concerns the gene BRCA2 and hereditary chronic pancreatitis.