<b>Background</b>: G<sub>M1</sub>-gangliosidosis (G<sub>M1</sub>) is a lysosomal storage disorder caused by mutations in the <i>Glb1</i> gene, resulting in reduced β-galactosidase activity and accumulation of G<sub>M1</sub> gangliosides in neuronal lysosomes. This evidence concerns the gene GLB1 and lysosomal storage disease.