<i>OAS1</i>, <i>OAS2</i>, and <i>OAS3</i> were overexpressed in hospitalized patients with severe COVID-19 compared with healthy subjects (HS) (log<sub>2</sub> fold change [95% CI]: <i>OAS2</i>: 4.312 [4.161-4.602], <i>OAS3</i>: 1.660 [1.485-1.916]; <i>p</i> = 0.0040 for both). This evidence concerns the gene OAS2 and COVID-19.