<b>Results</b>: We observed significant associations between the expression of two genes, Thyroid Hormone Receptor-Associated Protein 3 (<i>THRAP3</i>) (h<sup>2</sup> = 0.56 [0.45, 0.67]) and ADAM Metallopeptidase with Thrombospondin Type 1 Motif 7 (<i>ADAMTS7</i>) (h<sup>2</sup> = 0.66 [0.55, 0.77]), with depression and multiple MASLD-related phenotypes. This evidence concerns the gene THRAP3 and major depressive disorder.