<b>Results</b>: Here we found three novel loci for calcium nephrolithiasis: <i>SORBS2</i> on 4q35.1 (rs3736194; <i>p</i> = 2.84 × 10<sup>-13</sup>, OR = 0.6279), <i>CXXC5</i> on 5q31.2 (rs356450; <i>p</i> = 6.09 × 10<sup>-16</sup>, OR = 2.0312), and <i>MBD2</i> on 18q21.21 (rs55826947; <i>p</i> = 6.29 × 10<sup>-10</sup>, OR = 0.6017). Here, CXXC5 is linked to Calcium nephrolithiasis.