In addition, haplotype analysis demonstrated that a variant genotype of <i>TLR2</i> rs111200466 together with a wildtype of <i>TLR10</i> SNPs (rs10856837 and rs11096956) may protect against coexisting pneumonia (OR 0.2; 95% CI 0.06-0.6; <i>p</i> = 0.007).<h4>Conclusions</h4>This study suggests an association between coexisting infection and genetic variation in <i>TLR2</i> and <i>TLR10</i> of bacterial meningitis in Angolan children. Here, TLR2 is linked to bacterial meningitis.