IRF5 and melanoma: These findings suggest a modest modulatory effect of <i>IRF5</i> at the haplotypic level, likely driven by combined variant effects.<h4>Conclusions</h4>In conclusion, the present study did not identify statistically significant associations between the <i>IRF5</i> single-nucleotide variants rs3807135, rs3757385, and rs3778754 and melanoma risk in the analyzed population from western Mexico.