IL-10 (10 or 50 ng) was injected into adipose tissue of type 2 DM (T2DM) (<i>Lepr<sup>db</sup></i><sup>/<i>db</i></sup>) mice to investigate its effect on blood dipeptidyl peptidase-4 (DPP4) activity, insulin resistance, and hepatic gluconeogenic signaling. This evidence concerns the gene IL10 and type 2 diabetes mellitus.