Eleven patients (4.5%) harbored germline PVs/LPVs in cancer susceptibility genes including <i>STK11</i>, <i>TP53</i>, <i>BRCA1</i>, <i>BRCA2</i>, <i>FANCA</i>, <i>SLX4</i>, <i>RAD50</i>, <i>MSH6</i>, <i>POLD1</i> and <i>NF1</i>. The gene discussed is POLD1; the disease is cancer.