Further single-cell RNA sequencing (scRNA-seq) and immune cell correlation analyses revealed that <i>Leukotriene B4 receptor 1</i> (<i>LTB4R</i>) is primarily expressed in macrophages, T cells, and other immune cells, with a significant negative correlation observed with M1-type macrophages, suggesting its potential pro-tumourigenic role in CRC by suppressing M1 macrophage. The gene discussed is LTB4R; the disease is colorectal carcinoma.