<b>Background/Objectives:</b> We evaluated a 6-day repeated resveratrol exposure regimen in a three-dimensional (3D) culture model of human renal cell carcinoma (Caki-1) spheroids to examine phenotypic responses and changes in CIP2A abundance and epithelial-mesenchymal transition (EMT)-associated marker expression. The gene discussed is CIP2A; the disease is hereditary clear cell renal cell carcinoma.