Knock-in mice heterozygous for a glycine-to-serine point mutation in the ORAI1 pore (<i>ORAI1<sup>G100S/+</sup></i> or GS mice) phenocopy several key aspects of TAM in humans with the analogous mutation including muscle weakness, exercise intolerance, elevated CK levels, hypocalcemia, and the presence of tubular aggregates. This evidence concerns the gene ORAI1 and Hypocalcemia.