Nobiletin Ameliorates Alzheimer's Disease Pathology by Reducing Oxidative Stress and Neuroinflammation Through the AMPK/SIRT1/PGC-1&lt;i&gt;α&lt;/i&gt; and PI3K/Akt-CREB-BDNF Pathways in 5XFAD Mice. Here, CREB1 is linked to early-onset autosomal dominant Alzheimer disease.