Histopathology and immunohistochemistry (p63, SMA, CK5/6 positive; PSA, NKX3.1, and AR negative, with downregulated PSMA-expression) established the diagnosis of low-grade epithelial-myoepithelial carcinoma of the trachea. The gene discussed is FOLH1; the disease is epithelial-myoepithelial carcinoma.