Histopathology and immunohistochemistry (p63, SMA, CK5/6 positive; PSA, NKX3.1, and AR negative, with downregulated PSMA-expression) established the diagnosis of low-grade epithelial-myoepithelial carcinoma of the trachea. This evidence concerns the gene KRT5 and epithelial-myoepithelial carcinoma.