In <i>n</i> = 1333 individuals (60.1% females, median baseline age: 48.0 years [37.7; 58.0]), serum total CoQ10, ubiquinol, ubiquinone, and CoQ10 redox state were measured at baseline and found to be related to all-cause mortality using Cox regression models (adjusted for sex, age, body mass index, smoking, systolic blood pressure, total cholesterol, diabetes, and C-reactive protein). This evidence concerns the gene CRP and diabetes mellitus.