CSF cholinesterase was significantly different in group D compared with groups A, B and C (<i>p</i> = 0.003, <i>p</i> = 0.025, and <i>p</i> = 0.033, respectively).<h4>Conclusions</h4>Structural epilepsy may influence PON1 and cholinesterase levels in CSF samples. This evidence concerns the gene BCHE and epilepsy.