Membrane depolarization activates the NLRP3 inflammasome, with downregulation of endothelial Ca<sup>2+</sup>-activated K<sup>+</sup> channels type 2.3 (K<sub>Ca</sub> 2.3) and upregulation of endothelin-1 (ET-1) linked to erectile dysfunction. This evidence concerns the gene EDN1 and erectile dysfunction.