Transient receptor potential vanilloid subtype 1 (TRPV1), a non-selective cation channel extensively expressed in the cardiovascular system, has been implicated in the pathogenesis and progression of various CVDs, including myocardial infarction, ischemia-reperfusion injury, adverse cardiac remodeling, heart failure, hypertension, and diabetes. This evidence concerns the gene TRPV1 and heart failure.