We evaluated whether EC modulates obesity-associated DNA methylation changes using complementary in silico, in vitro, and in vivo approaches.<h4>Methods</h4>In silico analyses were performed to explore potential EC interactions with the DNA methyltransferases DNMT1, DNMT3A, and DNMT3B. Here, DNMT1 is linked to obesity due to melanocortin 4 receptor deficiency.