In contrast, among participants with T2D, insulin treatment emerged as the strongest independent predictor of engagement (β = 0.996, 95% CI 0.859-1.134, <i>p</i> < 0.001), and diabetes-related stress emerged as an independent predictor of engagement (β = 0.069, 95% CI 0.006-0.132, <i>p</i> = 0.033). The gene discussed is INS; the disease is diabetes mellitus.