EGFR and cardiovascular disorder: Downstream of Egfr, we identified sex-dependent activation of PKC signaling in male and ERK/MAPK signaling in female as mediators of Ctgf expression.<h4>Conclusion</h4>Overall, the relevance of AngII-calcineurin signaling for pathophysiological effects in the vasculature differs between female and male mice, suggesting both sexes require customized prevention and treatment strategies for cardiovascular disorders.