While aberrant H19 promoter methylation and expression have been linked to various bone metabolic disorders such as osteoporosis and osteosarcoma, their specific role in the pathogenesis of GC-induced ONFH remains largely unexplored.<h4>Methods</h4>We analyzed H19 promoter methylation, DNMTs, and H19 expression in human ONFH BMSCs. This evidence concerns the gene H19 and osteosarcoma.