Pre-treatment sRAGE levels were strongly correlated with post-treatment levels (Pearson's r = 0.78; 95% CI, 0.61-0.88; <i>p</i> = 4.1 × 10<sup>-9</sup>) and moderately correlated with PD-L1 tumor proportion score in NSCLC patients (Spearman's ρ = 0.4, <i>p</i> = 0.049). This evidence concerns the gene CD274 and neoplasm.