STAT4 and hypertriglyceridemia: The identified outliers were characterized using robust PCA, co-expression networks, unsupervised clustering, and Random Forest predictive modeling.<h4>Results</h4>In the clinical cohort, an outlier subgroup (47.3%) exhibited an extreme immune-metabolic phenotype characterized by hyperactivation of Th1/Th17 pathways (elevated T-bet and IL-17; <i>p</i> < 0.001), hypertriglyceridemia, and network reconfiguration (TGFβ and STAT4 hubs).