Children with segmental/lobar <i>Mycoplasma</i> pneumonia were more likely to present with prolonged fever (>5 days), lymphocytopenia, a neutrophil-to-lymphocyte ratio (NLR) ≥ 3, and elevated C-reactive protein (CRP) levels, each of which was strongly associated with macrolide non-response (all <i>p</i> < 0.001). This evidence concerns the gene CRP and pneumonia.