The epigenetic insights that were obtained can help elucidate the transcription regulation of some of these genes (e.g., <i>MUSK</i>, <i>RAPSN</i>, <i>HEYL</i>, <i>SYNPO2</i>, <i>SYNPO2L</i>, <i>STAC3</i>, <i>PITX2</i>, and <i>TPPP3</i>) that are implicated in congenital myasthenic syndromes, myasthenia gravis, muscle repair, heart dysfunction, or cancer. The gene discussed is PITX2; the disease is congenital myasthenic syndrome.